PLEKHO2

Across TCGA cell cohorts, PLEKHO2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PLEKHO2-associated genes across cancer lineages are TMSB4Y, GSG1L2, and OR6B3. Each is linked with PLEKHO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHO2-to-partner and partner-to-PLEKHO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMSB4Y grouped by PLEKHO2-low versus PLEKHO2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO2→partner) and Y-score (partner→PLEKHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMSB4Y →	+1.595	+3.556	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
SKIN	OR6B3 →	+0.136	+6.022	<.001	.001	3	1
LUNG_NSCLC_LUAD	RESP18 →	+0.023	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	CRYBA4 →	+0.041	+3.215	.009	.007	3	1
LUNG_NSCLC_LUAD	TMEM211 →	+0.059	+3.605	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TMSB4Y by PLEKHO2 expression — LARGE_INTESTINE

Explore this box plot interactively →