PLEKHO2

Across TCGA cell cohorts, PLEKHO2 mutation is significantly associated with the mutation status of many other genes, with 2,699 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHO2-associated genes across cancer lineages are EPG5, GTF3C1, and BRD8. Each is linked with PLEKHO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHO2-to-partner and partner-to-PLEKHO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPG5 grouped by PLEKHO2-low versus PLEKHO2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO2→partner) and Y-score (partner→PLEKHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EPG5 →	+4.392	+4.954	.008	.008	1	4
LUNG_NSCLC_LUAD	GTF3C1 →	+2.478	+3.019	.006	.006	1	3
UPPER_AERODIGESTIVE_TRACT	BRD8 →	+5.392	+5.392	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	RTN4 →	+4.392	+4.954	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	PRG4 →	+4.392	+4.954	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	GFPT2 →	+4.392	+4.954	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,699 associations by consensus.

EPG5 by PLEKHO2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →