PLEKHO1

Across TCGA patient cohorts, PLEKHO1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,134 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHO1-associated genes across cancer lineages are CYTH4, SLA2, and TLR8. Each is linked with PLEKHO1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEKHO1-to-partner and partner-to-PLEKHO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHO1 versus CYTH4 in HNSC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO1→partner) and Y-score (partner→PLEKHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYTH4 →	+1.304	+0.432	<.001	<.001	3	7
BRCA	SLA2 →	+0.857	+0.321	<.001	<.001	3	7
HNSC	TLR8 →	+1.290	+0.473	<.001	<.001	3	7
HNSC	LILRB1 →	+1.328	+0.488	<.001	<.001	3	7
HNSC	CD4 →	+0.925	+0.352	<.001	<.001	3	7
UCEC	IL10RA →	+0.994	+0.500	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,134 associations by consensus.

PLEKHO1 vs CYTH4 — HNSC

Explore this scatter interactively →