PLEKHO1

Across TCGA patient cohorts, PLEKHO1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHO1-associated genes across cancer lineages are ATM, Lck, and Src_pY527. Each is linked with PLEKHO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHO1-to-partner and partner-to-PLEKHO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PLEKHO1-low versus PLEKHO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO1→partner) and Y-score (partner→PLEKHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.570	-2.321	.012	.035	3	2
UCEC	Lck →	+0.239	+2.321	.017	.035	3	1
UCEC	Src_pY527 →	-0.476	-2.990	.027	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.964	+3.189	.001	.010	3	1
UCEC	EGFR_pY1068 →	-0.248	-2.321	.049	.035	2	1
UCEC	Akt_pS473 →	-0.829	-2.321	.021	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ATM by PLEKHO1 expression — UCEC

Explore this box plot interactively →