PLEKHO1

Across TCGA cell cohorts, PLEKHO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,809 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHO1-associated GO terms across cancer lineages are Regulation of metaphase/anaphase transition of cell cycle, Regulation of DNA repair, and Protein-DNA complex organization. Each is linked with PLEKHO1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PLEKHO1-to-partner and partner-to-PLEKHO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase/anaphase transition of cell cycle grouped by PLEKHO1-low versus PLEKHO1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO1→partner) and Y-score (partner→PLEKHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of metaphase/anaphase transition of cell cycle →	+0.105	+2.833	<.001	<.001	3	13
STOMACH	Regulation of DNA repair →	+0.050	+2.340	.002	<.001	3	13
LUNG_NSCLC_LUSC	Protein-DNA complex organization →	+0.063	+2.230	<.001	.001	3	12
LUNG_SCLC	Positive regulation of double-strand break repair via homologous recombination →	+0.081	+1.115	.003	.005	3	12
LUNG_SCLC	Regulation of ubiquitin protein ligase activity →	+0.183	+1.850	<.001	<.001	3	12
URINARY_TRACT	Regulation of sister chromatid segregation →	+0.110	+2.215	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,809 associations by consensus.

Regulation of metaphase/anaphase transition of cell cycle by PLEKHO1 expression — STOMACH

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