Across TCGA pan-cancer cohorts, PLEKHN1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PLEKHN1 data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PLEKHN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PLEKHN1 expression acts as an unfavorable survival marker.

THYM, UCEC, and SKCM are the cancer types where PLEKHN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.186	0.931	<.001	15	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PLEKHN1 tumor-vs-normal RNA expression · all PLEKHN1 data types