Across TCGA patient cohorts, PLEKHN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,221 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHN1-associated proteins across cancer lineages are FOSL2_S230, PPL, and S100A16. Each is linked with PLEKHN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLEKHN1-to-partner and partner-to-PLEKHN1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHN1→partner) and Y-score (partner→PLEKHN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FOSL2_S230 →	+0.547	+0.580	<.001	<.001	3	6
HNSC	PPL →	+0.772	+0.842	<.001	<.001	3	6
UCEC	S100A16 →	+0.617	+0.596	<.001	<.001	3	5
UCEC	SERPINB5 →	+1.300	+0.618	<.001	<.001	2	6
LUAD	ANXA1 →	+0.526	+0.653	<.001	<.001	3	5
LUAD	FOSL2 →	+0.488	+0.662	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,221 associations by consensus.

Exploration

PLEKHN1 survival (RNA) · tumor vs normal (RNA) · all PLEKHN1 data types