Across TCGA patient cohorts, PLEKHN1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHN1-associated genes across cancer lineages are ERK2, MSH2, and BRD4. Each is linked with PLEKHN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHN1-to-partner and partner-to-PLEKHN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHN1→partner) and Y-score (partner→PLEKHN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.246	+3.000	.015	.036	3	1
UCEC	MSH2 →	-0.297	-2.990	.014	.036	3	1
UCEC	BRD4 →	+0.403	+3.177	.006	.010	2	1
UCEC	GATA6 →	-0.214	-3.162	.011	.019	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

PLEKHN1 survival (RNA) · tumor vs normal (RNA) · all PLEKHN1 data types