Across TCGA cell cohorts, PLEKHN1 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PLEKHN1-associated genes across cancer lineages are CBY1, ASPN, and ZNHIT6. Each is linked with PLEKHN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHN1-to-partner and partner-to-PLEKHN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHN1→partner) and Y-score (partner→PLEKHN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.674	+3.160	.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.039	+3.841	<.001	<.001	3	1
LARGE_INTESTINE	ZNHIT6 →	+0.670	+3.131	.001	.008	3	1
LARGE_INTESTINE	VPS26A →	+0.615	+3.067	<.001	.009	3	1
LARGE_INTESTINE	NIP7 →	+0.632	+3.067	<.001	.009	3	1
LARGE_INTESTINE	PNLDC1 →	+0.073	+3.302	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

Exploration

PLEKHN1 survival (RNA) · tumor vs normal (RNA) · all PLEKHN1 data types