PLEKHM3

Across TCGA patient cohorts, PLEKHM3 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,293 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHM3-associated proteins across cancer lineages are LYAR_S260, MAN2A1, and NIF3L1. Each is linked with PLEKHM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHM3-to-partner and partner-to-PLEKHM3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHM3 versus LYAR_S260 in HNSC, with a Pearson correlation of -0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM3→partner) and Y-score (partner→PLEKHM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LYAR_S260 →	-0.850	-0.469	<.001	<.001	3	5
GBM	MAN2A1 →	-0.455	-0.347	.005	.001	3	5
PDAC	NIF3L1 →	+0.252	+0.179	<.001	.002	3	5
HNSC	TRIM2 →	+0.542	+0.413	<.001	<.001	3	5
GBM	PSIP1 →	+0.589	+0.394	<.001	<.001	3	5
PDAC	RCSD1_S68 →	-0.386	-0.262	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,293 associations by consensus.

PLEKHM3 vs LYAR_S260 — HNSC

Explore this scatter interactively →