PLEKHM3

Across TCGA patient cohorts, PLEKHM3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHM3-associated genes across cancer lineages are ASNS, GAPDH, and JNK_pT183_Y185. Each is linked with PLEKHM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHM3-to-partner and partner-to-PLEKHM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PLEKHM3-low versus PLEKHM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM3→partner) and Y-score (partner→PLEKHM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.337	+1.584	.017	.036	3	3
UCEC	GAPDH →	+0.561	+3.459	.007	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.192	-2.000	.003	.030	3	2
UCEC	Akt_pT308 →	+0.514	+3.169	.037	.018	3	2
UCEC	PCNA →	+0.195	+1.700	.021	.042	3	2
UCEC	ATM →	-0.692	-2.502	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ASNS by PLEKHM3 expression — UCEC

Explore this box plot interactively →