PLEKHM3

Across TCGA cell cohorts, PLEKHM3 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHM3-associated genes across cancer lineages are OR10K1, MDFIC2, and C20orf85. Each is linked with PLEKHM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHM3-to-partner and partner-to-PLEKHM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K1 grouped by PLEKHM3-low versus PLEKHM3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM3→partner) and Y-score (partner→PLEKHM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10K1 →	+0.443	+4.234	<.001	.003	3	2
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	KLRD1 →	+0.201	+3.769	<.001	.008	3	1
BLOOD_Leukemia	BTBD16 →	+0.082	+3.959	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

OR10K1 by PLEKHM3 expression — BLOOD_Leukemia

Explore this box plot interactively →