Across TCGA patient cohorts, PLEKHM1P1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHM1P1-associated genes across cancer lineages are ER-alpha, VEGFR2, and ASNS. Each is linked with PLEKHM1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHM1P1-to-partner and partner-to-PLEKHM1P1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM1P1→partner) and Y-score (partner→PLEKHM1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-0.846	-3.459	.040	.005	3	2
UCEC	VEGFR2 →	+0.591	+3.472	<.001	.002	3	2
UCEC	ASNS →	+0.523	+3.000	.003	.036	3	2
UCEC	ERK2 →	+0.256	+2.321	.008	.035	3	1
UCEC	IGFBP2 →	-0.742	-2.321	.022	.035	3	1
UCEC	PDCD4 →	-0.547	-2.321	.020	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

PLEKHM1P1 survival (RNA) · tumor vs normal (RNA) · all PLEKHM1P1 data types