Across TCGA patient cohorts, PLEKHM1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHM1-associated genes across cancer lineages are PCNA, C-Raf_pS338, and eIF4E. Each is linked with PLEKHM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHM1-to-partner and partner-to-PLEKHM1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM1→partner) and Y-score (partner→PLEKHM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.216	+1.847	.001	.007	3	3
COAD	C-Raf_pS338 →	+0.184	+3.008	.026	.019	3	2
UCEC	eIF4E →	+0.148	+2.183	.027	.033	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.460	-2.169	.001	.003	3	2
UCEC	p62 Lck ligand →	+0.278	+1.916	.007	.009	3	2
UCEC	Rad50 →	-0.242	-3.893	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

PLEKHM1 survival (RNA) · tumor vs normal (RNA) · all PLEKHM1 data types