PLEKHJ1

Across TCGA cell cohorts, PLEKHJ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,811 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLEKHJ1-associated GO terms across cancer lineages are Energy coupled proton transmembrane transport, against electrochemical gradient, Electron transport coupled proton transport, and Cytoplasm protein quality control by the ubiquitin-proteasome system. Each is linked with PLEKHJ1 in more than 17 cancer types. Because this analysis shows association rather than direction, both PLEKHJ1-to-partner and partner-to-PLEKHJ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Energy coupled proton transmembrane transport, against electrochemical gradient grouped by PLEKHJ1-low versus PLEKHJ1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHJ1→partner) and Y-score (partner→PLEKHJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.096	+0.996	.003	.004	3	18
BONE	Electron transport coupled proton transport →	+0.096	+0.996	.003	.004	3	18
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.164	+0.855	<.001	<.001	3	16
BONE	Cytoplasm protein quality control →	+0.140	+0.844	<.001	<.001	3	15
LIVER	Regulation of protein localization to chromatin →	+0.121	+0.818	.003	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.155	+0.688	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,811 associations by consensus.

Energy coupled proton transmembrane transport, against electrochemical gradient by PLEKHJ1 expression — BONE

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