PLEKHH3

Across TCGA patient cohorts, PLEKHH3 protein abundance is significantly associated with the RNA expression of many other genes, with 7,190 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PLEKHH3-associated genes across cancer lineages are C1orf195, PZP, and LINC01620. Each is linked with PLEKHH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHH3-to-partner and partner-to-PLEKHH3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHH3 versus C1orf195 in PDAC, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH3→partner) and Y-score (partner→PLEKHH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	C1orf195 →	-0.660	-0.670	<.001	.006	3	3
LSCC	PZP →	-0.636	-0.426	<.001	.001	3	2
OV	LINC01620 →	-0.077	-1.225	.004	<.001	3	2
OV	FUT2 →	+1.910	+1.276	.002	.002	3	2
OV	PCAT19 →	-0.632	-0.690	.009	.007	3	2
COAD	VAT1 →	+1.564	+0.358	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,190 associations by consensus.

PLEKHH3 vs C1orf195 — PDAC

Explore this scatter interactively →