PLEKHH3

Across TCGA patient cohorts, PLEKHH3 mutation is significantly associated with the RNA expression of many other genes, with 1,661 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHH3-associated genes across cancer lineages are YWHAEP2, RNU6-275P, and MIR8086. Each is linked with PLEKHH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHH3-to-partner and partner-to-PLEKHH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YWHAEP2 grouped by PLEKHH3-low versus PLEKHH3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH3→partner) and Y-score (partner→PLEKHH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	YWHAEP2 →	+0.195	+5.164	<.001	.002	3	2
CESC	RNU6-275P →	+0.224	+4.569	<.001	.005	3	2
LUAD	MIR8086 →	+0.500	+4.722	.002	.003	3	2
SKCM	UBE2V1P5 →	+0.181	+4.075	<.001	.004	3	2
UCEC	ZNF285 →	-0.564	-2.392	<.001	<.001	3	2
UCEC	NDUFV2P1 →	+0.491	+1.684	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,661 associations by consensus.

YWHAEP2 by PLEKHH3 expression — CESC

Explore this box plot interactively →