PLEKHH3

Across TCGA patient cohorts, PLEKHH3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHH3-associated genes across cancer lineages are FASN, p62 Lck ligand, and VHL. Each is linked with PLEKHH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHH3-to-partner and partner-to-PLEKHH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PLEKHH3-low versus PLEKHH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH3→partner) and Y-score (partner→PLEKHH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.393	+3.169	.013	.018	3	2
UCEC	p62 Lck ligand →	+0.489	+3.584	<.001	.002	3	2
UCEC	VHL →	-0.704	-1.874	.009	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.678	+3.321	.004	.009	3	2
UCEC	A-Raf_pS299 →	-0.139	-2.459	.003	.019	3	1
UCEC	FoxM1 →	+0.230	+2.415	.027	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FASN by PLEKHH3 expression — UCEC

Explore this box plot interactively →