PLEKHH3

Across TCGA cell cohorts, PLEKHH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,773 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PLEKHH3-associated GO terms across cancer lineages are Cellular response to morphine, Cellular response to isoquinoline alkaloid, and Cilium or flagellum-dependent cell motility. Each is linked with PLEKHH3 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLEKHH3-to-partner and partner-to-PLEKHH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to morphine grouped by PLEKHH3-low versus PLEKHH3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH3→partner) and Y-score (partner→PLEKHH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cellular response to morphine →	+0.174	+0.990	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cellular response to isoquinoline alkaloid →	+0.174	+0.990	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.095	-0.896	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.093	+1.221	<.001	<.001	3	9
CNS	Endosomal lumen acidification →	+0.125	+0.776	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.095	-0.896	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,773 associations by consensus.

Cellular response to morphine by PLEKHH3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →