PLEKHH3

Across TCGA cell cohorts, PLEKHH3 mutation is significantly associated with the RNA expression of many other genes, with 425 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHH3-associated genes across cancer lineages are IQCF5, F13B, and SPATA19. Each is linked with PLEKHH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHH3-to-partner and partner-to-PLEKHH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by PLEKHH3-low versus PLEKHH3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH3→partner) and Y-score (partner→PLEKHH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	2
LARGE_INTESTINE	F13B →	+0.048	+2.242	.003	.007	3	2
BLOOD_Myeloma	SPATA19 →	+0.033	+4.807	<.001	.006	3	1
SOFT_TISSUE	NEU2 →	+0.058	+4.882	<.001	.001	3	1
LUNG_SCLC	OR1N2 →	+0.025	+5.029	<.001	.006	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

IQCF5 by PLEKHH3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →