PLEKHH2

Across TCGA patient cohorts, PLEKHH2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,521 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHH2-associated genes across cancer lineages are PLK4, MAD2L1, and DEPDC1. Each is linked with PLEKHH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHH2-to-partner and partner-to-PLEKHH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHH2 versus PLK4 in LUAD, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH2→partner) and Y-score (partner→PLEKHH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLK4 →	-0.789	-0.381	<.001	<.001	3	4
LSCC	MAD2L1 →	-0.805	-0.335	<.001	<.001	3	4
LUAD	DEPDC1 →	-1.155	-0.423	<.001	<.001	3	4
LUAD	CDKN3 →	-0.694	-0.318	<.001	<.001	3	3
PDAC	NCAPG →	-0.768	-0.590	<.001	.003	3	3
LUAD	FBXO5 →	-0.668	-0.411	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,521 associations by consensus.

PLEKHH2 vs PLK4 — LUAD

Explore this scatter interactively →