PLEKHH2

Across TCGA patient cohorts, PLEKHH2 mutation is significantly associated with the RNA expression of many other genes, with 8,737 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHH2-associated genes across cancer lineages are SHMT2, DRG1, and CHAF1A. Each is linked with PLEKHH2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHH2-to-partner and partner-to-PLEKHH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHMT2 grouped by PLEKHH2-low versus PLEKHH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH2→partner) and Y-score (partner→PLEKHH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SHMT2 →	+0.558	+1.584	<.001	<.001	3	5
UCEC	DRG1 →	+0.380	+1.918	<.001	<.001	3	5
UCEC	CHAF1A →	+0.788	+4.269	<.001	<.001	3	5
UCEC	TTLL12 →	+0.471	+1.233	<.001	<.001	3	5
UCEC	CCT7 →	+0.359	+1.480	<.001	<.001	3	5
UCEC	CKS1B →	+0.613	+1.716	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,737 associations by consensus.

SHMT2 by PLEKHH2 expression — UCEC

Explore this box plot interactively →