PLEKHH2

Across TCGA patient cohorts, PLEKHH2 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHH2-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and TFRC. Each is linked with PLEKHH2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLEKHH2-to-partner and partner-to-PLEKHH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PLEKHH2-low versus PLEKHH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH2→partner) and Y-score (partner→PLEKHH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.546	+2.078	<.001	<.001	3	6
UCEC	Cyclin-B1 →	+0.743	+1.925	<.001	<.001	3	5
BRCA	TFRC →	+0.531	+2.459	.009	.021	3	4
SKCM	Cyclin-E2 →	+0.170	+2.472	.006	.010	3	4
UCEC	PDCD4 →	-0.460	-1.584	<.001	<.001	3	4
LUSC	PREX1 →	-0.286	-2.990	.004	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Caspase-7-cleavedD198 by PLEKHH2 expression — UCEC

Explore this box plot interactively →