PLEKHH2

Across TCGA cell cohorts, PLEKHH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,669 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PLEKHH2-associated GO terms across cancer lineages are Regulation of myoblast fusion, Regulation of syncytium formation by plasma membrane fusion, and Golgi vesicle transport. Each is linked with PLEKHH2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PLEKHH2-to-partner and partner-to-PLEKHH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by PLEKHH2-low versus PLEKHH2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH2→partner) and Y-score (partner→PLEKHH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of myoblast fusion →	+0.123	+1.403	<.001	.001	3	11
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.113	+1.268	<.001	.001	3	11
OESOPHAGUS	Golgi vesicle transport →	+0.069	+1.338	.001	.001	2	12
LUNG_SCLC	Protein targeting →	+0.064	+2.429	<.001	<.001	3	10
BREAST	Cytoplasmic translation →	+0.096	+1.267	<.001	.001	3	10
OVARY	Positive regulation of L-glutamate import across plasma membrane →	+0.041	+0.813	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,669 associations by consensus.

Regulation of myoblast fusion by PLEKHH2 expression — BREAST

Explore this box plot interactively →