PLEKHH2

Across TCGA cell cohorts, PLEKHH2 mutation is significantly associated with the RNA expression of many other genes, with 130 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHH2-associated genes across cancer lineages are VSIG4, PRB1, and OR56A4. Each is linked with PLEKHH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHH2-to-partner and partner-to-PLEKHH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSIG4 grouped by PLEKHH2-low versus PLEKHH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH2→partner) and Y-score (partner→PLEKHH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VSIG4 →	+0.023	+2.054	<.001	.008	3	3
BLOOD_Lymphoma	PRB1 →	+0.052	+5.087	<.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	OR56A4 →	+0.035	+3.870	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	OR2J2 →	+0.059	+4.925	<.001	<.001	3	2
BLOOD_Leukemia	OBP2A →	+0.044	+4.984	<.001	.002	3	2
PANCREAS	GZMH →	+0.056	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 130 associations by consensus.

VSIG4 by PLEKHH2 expression — LARGE_INTESTINE

Explore this box plot interactively →