PLEKHH1

Across TCGA patient cohorts, PLEKHH1 protein abundance is significantly associated with the RNA expression of many other genes, with 551 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHH1-associated genes across cancer lineages are DICER1, ARL2BP, and DCTN6. Each is linked with PLEKHH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHH1-to-partner and partner-to-PLEKHH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHH1 versus DICER1 in GBM, with a Pearson correlation of 0.94.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH1→partner) and Y-score (partner→PLEKHH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DICER1 →	+0.719	+1.173	.002	.004	3	1
GBM	ARL2BP →	-1.423	-1.216	<.001	.002	3	1
GBM	DCTN6 →	+0.915	+1.355	.003	.002	3	1
GBM	SNX8 →	-0.663	-1.219	<.001	.002	3	1
GBM	LDHB →	+1.299	+1.169	.005	.004	3	1
GBM	ADPRS →	-0.623	-1.219	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 551 associations by consensus.

PLEKHH1 vs DICER1 — GBM

Explore this scatter interactively →