PLEKHH1

Across TCGA patient cohorts, PLEKHH1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHH1-associated genes across cancer lineages are Caspase-7-cleavedD198, GAPDH, and Rad50. Each is linked with PLEKHH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHH1-to-partner and partner-to-PLEKHH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PLEKHH1-low versus PLEKHH1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH1→partner) and Y-score (partner→PLEKHH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.452	+3.178	<.001	.010	3	3
UCEC	GAPDH →	+0.442	+2.321	.009	.005	3	3
COAD	Rad50 →	-0.279	-3.161	.019	.019	3	2
UCEC	EGFR_pY1068 →	-0.321	-2.378	<.001	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.180	-2.045	<.001	<.001	3	2
UCEC	PDCD4 →	-0.398	-1.584	.008	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Caspase-7-cleavedD198 by PLEKHH1 expression — COAD

Explore this box plot interactively →