PLEKHH1

Across TCGA cell cohorts, PLEKHH1 mutation is significantly associated with the RNA expression of many other genes, with 687 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHH1-associated genes across cancer lineages are GCAT, ZIC5, and PNLDC1. Each is linked with PLEKHH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHH1-to-partner and partner-to-PLEKHH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by PLEKHH1-low versus PLEKHH1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH1→partner) and Y-score (partner→PLEKHH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.269	+2.043	<.001	.008	3	2
LARGE_INTESTINE	ZIC5 →	+1.089	+3.321	<.001	.003	3	2
LARGE_INTESTINE	PNLDC1 →	+0.063	+3.321	<.001	.003	3	2
LARGE_INTESTINE	DNAH10 →	+0.480	+2.043	.006	.008	3	2
LARGE_INTESTINE	ZNF487 →	+0.847	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	TLE2 →	+1.308	+2.043	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 687 associations by consensus.

GCAT by PLEKHH1 expression — LARGE_INTESTINE

Explore this box plot interactively →