PLEKHH1

Across TCGA cell cohorts, PLEKHH1 mutation is significantly associated with the mutation status of many other genes, with 4,297 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHH1-associated genes across cancer lineages are AEBP1, BCLAF1, and GPATCH8. Each is linked with PLEKHH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHH1-to-partner and partner-to-PLEKHH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AEBP1 grouped by PLEKHH1-low versus PLEKHH1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH1→partner) and Y-score (partner→PLEKHH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AEBP1 →	+3.532	+3.357	.005	.005	1	5
LARGE_INTESTINE	BCLAF1 →	+2.341	+2.243	<.001	<.001	1	5
BLOOD_Leukemia	GPATCH8 →	+2.232	+2.282	.006	.006	1	5
LARGE_INTESTINE	BAZ2A →	+2.189	+1.886	.007	.007	1	5
SOFT_TISSUE	MYH4 →	+4.502	+5.066	.007	.007	1	4
OVARY	SYNM →	+4.415	+4.977	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,297 associations by consensus.

AEBP1 by PLEKHH1 expression — SKIN

Explore this box plot interactively →