Across TCGA pan-cancer cohorts, PLEKHG7 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated PLEKHG7 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PLEKHG7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PLEKHG7 expression acts as an unfavorable survival marker.

GBM are the cancer types where PLEKHG7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.075	0.416	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: PLEKHG7 tumor-vs-normal RNA expression · all PLEKHG7 data types