PLEKHG5

Across TCGA pan-cancer cohorts, PLEKHG5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PLEKHG5 data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PLEKHG5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PLEKHG5 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where PLEKHG5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.809	0.514	.005	35	view →
LSCC	OS	Quartile	All	0.669	1.000	.019	13	view →
LUAD	OS	Quartile	III,IV	0.225	0.931	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PLEKHG5–HNSC (DFS)

Open the HNSC breakdown →