PLEKHG5

Across TCGA patient cohorts, PLEKHG5 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,647 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PLEKHG5-associated proteins across cancer lineages are PLEKHG5_S224, PLEKHG5_S959, and SERPINB5. Each is linked with PLEKHG5 in more than 7 cancer types. Because this analysis shows association rather than direction, both PLEKHG5-to-partner and partner-to-PLEKHG5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG5 versus PLEKHG5_S224 in BRCA, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG5→partner) and Y-score (partner→PLEKHG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLEKHG5_S224 →	+0.700	+1.092	<.001	<.001	3	8
GBM	PLEKHG5_S959 →	+0.702	+1.147	<.001	<.001	3	7
HNSC	SERPINB5 →	+0.737	+0.611	<.001	<.001	3	4
HNSC	CDKN1B_S10 →	-0.468	-0.731	<.001	<.001	3	4
OV	FSCN1 →	+0.643	+1.069	<.001	<.001	3	4
UCEC	ESPN →	+0.870	+1.039	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,647 associations by consensus.

PLEKHG5 vs PLEKHG5_S224 — BRCA

Explore this scatter interactively →