PLEKHG5

Across TCGA patient cohorts, PLEKHG5 protein abundance is significantly associated with the RNA expression of many other genes, with 2,508 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PLEKHG5-associated genes across cancer lineages are RPLP2, SOWAHA, and HSPG2. Each is linked with PLEKHG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG5-to-partner and partner-to-PLEKHG5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG5 versus RPLP2 in OV, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG5→partner) and Y-score (partner→PLEKHG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPLP2 →	-0.722	-0.862	.007	<.001	3	2
OV	SOWAHA →	+1.258	+0.824	<.001	.001	3	2
LSCC	HSPG2 →	+0.982	+0.574	.002	.009	3	2
BRCA	HES2 →	+1.190	+0.560	<.001	.006	3	2
UCEC	TSNAXIP1 →	+1.218	+0.646	.001	<.001	3	2
UCEC	SPATA18 →	+1.526	+0.833	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,508 associations by consensus.

PLEKHG5 vs RPLP2 — OV

Explore this scatter interactively →