PLEKHG5

Across TCGA patient cohorts, PLEKHG5 mutation is significantly associated with the RNA expression of many other genes, with 851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG5-associated genes across cancer lineages are RTKN2, RN7SL22P, and CKS2. Each is linked with PLEKHG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHG5-to-partner and partner-to-PLEKHG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTKN2 grouped by PLEKHG5-low versus PLEKHG5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG5→partner) and Y-score (partner→PLEKHG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RTKN2 →	+0.598	+3.207	.001	.009	3	3
BLCA	RN7SL22P →	+0.131	+3.973	<.001	.003	3	3
SKCM	CKS2 →	+0.829	+2.241	<.001	.006	3	3
SKCM	KIF11 →	+0.899	+3.347	<.001	.004	3	3
READ	RNU6-903P →	+0.597	+5.039	<.001	.008	3	2
SKCM	GAPDHP22 →	+0.302	+2.241	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 851 associations by consensus.

RTKN2 by PLEKHG5 expression — SKCM

Explore this box plot interactively →