PLEKHG5

Across TCGA patient cohorts, PLEKHG5 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG5-associated genes across cancer lineages are mTOR_pS2448, Chk1, and Lck. Each is linked with PLEKHG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHG5-to-partner and partner-to-PLEKHG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PLEKHG5-low versus PLEKHG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG5→partner) and Y-score (partner→PLEKHG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.143	-3.308	.020	.009	3	3
SKCM	Chk1 →	+0.195	+3.012	.041	.018	3	2
UCEC	Lck →	+0.169	+2.321	.041	.006	3	2
UCEC	MSH2 →	-0.232	-1.807	.014	.027	3	2
UCEC	MSH6 →	-0.460	-2.321	<.001	.033	3	2
UCEC	Annexin-1 →	+0.738	+3.604	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

mTOR_pS2448 by PLEKHG5 expression — UCEC

Explore this box plot interactively →