PLEKHG5

Across TCGA cell cohorts, PLEKHG5 mutation is significantly associated with the RNA expression of many other genes, with 621 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHG5-associated genes across cancer lineages are DPPA4, SPHKAP, and C12orf40. Each is linked with PLEKHG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG5-to-partner and partner-to-PLEKHG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPPA4 grouped by PLEKHG5-low versus PLEKHG5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG5→partner) and Y-score (partner→PLEKHG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DPPA4 →	+0.115	+3.129	.007	.004	3	1
SKIN	SPHKAP →	+0.013	+3.877	.002	.003	3	1
SKIN	C12orf40 →	+0.033	+2.925	<.001	.007	3	1
SKIN	OR10J5 →	+0.011	+3.700	<.001	.009	3	1
SKIN	OTUD6A →	+0.022	+3.217	<.001	.006	3	1
SKIN	CT47A1 →	+0.010	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 621 associations by consensus.

DPPA4 by PLEKHG5 expression — SKIN

Explore this box plot interactively →