Across TCGA patient cohorts, PLEKHG4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,613 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHG4-associated proteins across cancer lineages are PLEKHG4_S64, FUS, and CHAMP1. Each is linked with PLEKHG4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHG4-to-partner and partner-to-PLEKHG4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4→partner) and Y-score (partner→PLEKHG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLEKHG4_S64 →	+1.211	+1.521	<.001	<.001	3	5
LSCC	FUS →	+0.456	+1.260	<.001	<.001	3	5
HNSC	CHAMP1 →	+0.225	+0.832	.001	<.001	3	4
LSCC	TFAP4 →	+0.505	+1.355	<.001	<.001	3	4
LSCC	PRCC →	+0.324	+1.389	<.001	<.001	3	4
LSCC	SMC1A →	+0.258	+1.041	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,613 associations by consensus.

Exploration

PLEKHG4 survival (RNA) · tumor vs normal (RNA) · all PLEKHG4 data types