Across TCGA patient cohorts, PLEKHG4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,876 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHG4-associated genes across cancer lineages are SRPX2, MEDAG, and ELMO3. Each is linked with PLEKHG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHG4-to-partner and partner-to-PLEKHG4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4→partner) and Y-score (partner→PLEKHG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPX2 →	-1.203	-0.624	<.001	<.001	3	2
LSCC	MEDAG →	-1.135	-0.670	<.001	<.001	3	2
BRCA	ELMO3 →	+1.232	+0.590	<.001	.004	3	2
BRCA	ACD →	+0.887	+0.606	<.001	<.001	3	2
BRCA	TMC5 →	-1.643	-0.538	.003	<.001	3	2
GBM	IGDCC4 →	-2.031	-1.088	.004	.006	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,876 associations by consensus.

Exploration

PLEKHG4 survival (RNA) · tumor vs normal (RNA) · all PLEKHG4 data types