PLEKHG4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PLEKHG4 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG4-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and A-Raf_pS299. Each is linked with PLEKHG4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHG4-to-partner and partner-to-PLEKHG4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4→partner) and Y-score (partner→PLEKHG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADCaspase-7-cleavedD198 →+1.112+2.178.002.03534
UCECeIF4E →+0.182+1.716.007.00332
UCECA-Raf_pS299 →-0.092-1.807.017.02532
UCECERK2 →+0.150+1.502.016.02732
UCECMEK1 →+0.330+2.584.005.01032
UCECmTOR_pS2448 →-0.116-1.787.016.02632
Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

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