Across TCGA cell cohorts, PLEKHG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,474 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHG4-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Regulation of syncytium formation by plasma membrane fusion, and Viral process. Each is linked with PLEKHG4 in more than 11 cancer types. Because this analysis shows association rather than direction, both PLEKHG4-to-partner and partner-to-PLEKHG4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4→partner) and Y-score (partner→PLEKHG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.131	+1.883	<.001	.001	3	12
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.108	+2.220	.001	<.001	3	12
BONE	Viral process →	+0.080	+2.032	.001	.002	3	11
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.168	+1.975	<.001	.002	2	11
OESOPHAGUS	Regulation of myoblast fusion →	+0.147	+1.975	<.001	.002	3	9
OESOPHAGUS	Striated muscle contraction →	+0.077	+2.447	.001	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,474 associations by consensus.

Exploration

PLEKHG4 survival (RNA) · tumor vs normal (RNA) · all PLEKHG4 data types