Across TCGA cell cohorts, PLEKHG4 mutation is significantly associated with the RNA expression of many other genes, with 630 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHG4-associated genes across cancer lineages are FAM47A, ZNF679, and DPEP3. Each is linked with PLEKHG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG4-to-partner and partner-to-PLEKHG4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4→partner) and Y-score (partner→PLEKHG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FAM47A →	+0.004	+4.369	<.001	.008	3	2
BLOOD_Lymphoma	ZNF679 →	+0.239	+4.714	<.001	.002	3	2
LARGE_INTESTINE	DPEP3 →	+0.018	+2.015	.006	.005	3	2
LARGE_INTESTINE	ACTL7A →	+0.016	+2.086	.002	.009	3	2
BONE	TSPY8 →	+0.340	+5.169	<.001	.004	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 630 associations by consensus.

Exploration

PLEKHG4 survival (RNA) · tumor vs normal (RNA) · all PLEKHG4 data types