PLEKHG3

Across TCGA pan-cancer cohorts, PLEKHG3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PLEKHG3 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PLEKHG3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PLEKHG3 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

HNSC, LUAD, and COAD are the cancer types where PLEKHG3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.107	1.000	.010	44	view →
LUAD	DFS	Median	All	0.506	0.768	.001	40	view →
COAD	DFS	Median	All	1.000	0.876	.018	36	view →
GBM	OS	Quartile	All	0.349	0.812	<.001	18	view →
CCRCC	DFS	Tertile	All	1.000	0.665	.011	15	view →
PDAC	DFS	Median	III,IV	0.539	0.211	.013	10	view →
LSCC	OS	Tertile	II,III,IV	0.863	0.626	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PLEKHG3–HNSC (OS)

Open the HNSC breakdown →