PLEKHG3

Across TCGA patient cohorts, PLEKHG3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,980 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHG3-associated proteins across cancer lineages are PLEKHG3_S423, PLEKHG3_S433, and PLEKHG3_S631. Each is linked with PLEKHG3 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEKHG3-to-partner and partner-to-PLEKHG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG3 versus PLEKHG3_S423 in LUAD, with a Pearson correlation of 0.70.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG3→partner) and Y-score (partner→PLEKHG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLEKHG3_S423 →	+0.863	+0.725	<.001	<.001	3	7
PDAC	PLEKHG3_S433 →	+0.883	+0.752	<.001	<.001	3	7
LUAD	PLEKHG3_S631 →	+0.638	+0.678	<.001	<.001	3	6
CCRCC	PLEKHG3_S741 →	+1.551	+1.322	.003	.003	3	6
LUAD	PLEKHG3_S827 →	+0.805	+0.733	<.001	<.001	3	6
GBM	RRBP1 →	-0.350	-0.739	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,980 associations by consensus.

PLEKHG3 vs PLEKHG3_S423 — LUAD

Explore this scatter interactively →