PLEKHG3

Across TCGA patient cohorts, PLEKHG3 protein abundance is significantly associated with the RNA expression of many other genes, with 14,617 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHG3-associated genes across cancer lineages are SLIRP, EIF2S1, and PLEK2. Each is linked with PLEKHG3 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLEKHG3-to-partner and partner-to-PLEKHG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG3 versus SLIRP in HNSC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG3→partner) and Y-score (partner→PLEKHG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLIRP →	+1.146	+0.330	<.001	<.001	3	6
HNSC	EIF2S1 →	+0.533	+0.312	<.001	<.001	3	6
HNSC	PLEK2 →	+1.151	+0.290	<.001	<.001	3	5
HNSC	AHSA1 →	+1.081	+0.316	.004	.003	3	5
HNSC	SNW1 →	+0.470	+0.247	.002	.001	3	5
HNSC	ERH →	+0.964	+0.313	.004	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,617 associations by consensus.

PLEKHG3 vs SLIRP — HNSC

Explore this scatter interactively →