PLEKHG3

Across TCGA patient cohorts, PLEKHG3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG3-associated genes across cancer lineages are 4E-BP1, eIF4E, and PDCD4. Each is linked with PLEKHG3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHG3-to-partner and partner-to-PLEKHG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PLEKHG3-low versus PLEKHG3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG3→partner) and Y-score (partner→PLEKHG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.366	+3.000	.006	.033	3	4
UCEC	eIF4E →	+0.158	+2.087	.014	.005	3	3
UCEC	PDCD4 →	-0.351	-3.700	.014	.001	3	3
COAD	GSK-3_pS9 →	-0.450	-2.991	.026	.036	3	2
STAD	alpha-Catenin →	+0.265	+2.321	.026	.034	3	2
UCEC	MEK1 →	+0.356	+2.070	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

4E-BP1 by PLEKHG3 expression — STAD

Explore this box plot interactively →