PLEKHG3

Across TCGA cell cohorts, PLEKHG3 mutation is significantly associated with the RNA expression of many other genes, with 523 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHG3-associated genes across cancer lineages are CYB5D1, HES3, and SSMEM1. Each is linked with PLEKHG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHG3-to-partner and partner-to-PLEKHG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYB5D1 grouped by PLEKHG3-low versus PLEKHG3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG3→partner) and Y-score (partner→PLEKHG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CYB5D1 →	+1.061	+3.386	<.001	.001	3	3
CNS	HES3 →	+0.032	+4.321	<.001	.009	3	2
LUNG_NSCLC_LUAD	SSMEM1 →	+0.025	+2.070	.007	.007	3	2
LUNG_NSCLC_LUAD	KLHL28 →	+0.474	+2.621	.001	.003	3	2
LUNG_NSCLC_LUAD	CNR2 →	+0.103	+2.608	.001	<.001	3	2
LUNG_NSCLC_LUAD	CCDC196 →	+0.031	+2.384	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 523 associations by consensus.

CYB5D1 by PLEKHG3 expression — LARGE_INTESTINE

Explore this box plot interactively →