PLEKHG1

Across TCGA pan-cancer cohorts, PLEKHG1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PLEKHG1 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PLEKHG1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLEKHG1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where PLEKHG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.234	0.895	<.001	34	view →
CCRCC	OS	Tertile	II,III,IV	0.376	0.872	.002	15	view →
LUAD	OS	Tertile	II,III,IV	0.771	0.352	.006	4	view →
PDAC	DFS	Median	III,IV	0.451	0.252	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PLEKHG1–HNSC (DFS)

Open the HNSC breakdown →