PLEKHG1

Across TCGA patient cohorts, PLEKHG1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,287 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHG1-associated genes across cancer lineages are PDCL3P5, FBN1, and ZNF423. Each is linked with PLEKHG1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEKHG1-to-partner and partner-to-PLEKHG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG1 versus PDCL3P5 in UCEC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG1→partner) and Y-score (partner→PLEKHG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCL3P5 →	+0.912	+0.505	<.001	<.001	3	7
PDAC	FBN1 →	+0.716	+0.250	<.001	<.001	3	5
UCEC	ZNF423 →	+0.823	+0.299	<.001	<.001	3	4
PDAC	RNF146 →	+0.425	+0.279	<.001	<.001	3	4
UCEC	SOX5 →	+0.886	+0.325	<.001	.002	3	4
BRCA	GPR161 →	+0.869	+0.428	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,287 associations by consensus.

PLEKHG1 vs PDCL3P5 — UCEC

Explore this scatter interactively →