PLEKHG1

Across TCGA patient cohorts, PLEKHG1 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG1-associated genes across cancer lineages are VHL, mTOR_pS2448, and Rab25. Each is linked with PLEKHG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHG1-to-partner and partner-to-PLEKHG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by PLEKHG1-low versus PLEKHG1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG1→partner) and Y-score (partner→PLEKHG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	VHL →	-0.754	-2.906	.009	.001	3	3
UCEC	mTOR_pS2448 →	-0.133	-1.398	.001	.004	3	3
UCEC	Rab25 →	-0.273	-1.222	.003	.011	3	3
UCEC	Shc_pY317 →	-0.145	-1.415	<.001	.040	3	3
UCEC	Caspase-8 →	-0.294	-2.000	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.446	+1.784	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

VHL by PLEKHG1 expression — SKCM

Explore this box plot interactively →