PLEKHG1

Across TCGA cell cohorts, PLEKHG1 mutation is significantly associated with the RNA expression of many other genes, with 130 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHG1-associated genes across cancer lineages are OR2A2, LORICRIN, and C9orf92. Each is linked with PLEKHG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG1-to-partner and partner-to-PLEKHG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A2 grouped by PLEKHG1-low versus PLEKHG1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG1→partner) and Y-score (partner→PLEKHG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	1
SOFT_TISSUE	LORICRIN →	+0.032	+4.930	<.001	.008	3	1
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
LARGE_INTESTINE	SLC25A1 →	+0.808	+3.212	<.001	.006	3	1
LARGE_INTESTINE	JOSD1 →	+0.610	+3.212	.002	.006	3	1
LARGE_INTESTINE	HINT3 →	+0.662	+3.212	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 130 associations by consensus.

OR2A2 by PLEKHG1 expression — URINARY_TRACT

Explore this box plot interactively →